TelomereHunter2

TelomereHunter2 is a Python tool for estimating telomere content and analyzing telomeric variant repeats (TVRs) from genome sequencing data.

Key features

• Bulk analysis from BAM/CRAM
• Tumor vs control comparison (log2 ratio)
• Single-cell BAM support (barcode-aware)
• TSV outputs plus optional HTML reports and plots
• Docker/Apptainer support

Install

pip install telomerehunter2

Navigate

• Intro
• Quickstart
• Use cases
• scATAC annotation
• Tutorial videos
• FAQ

Citation

• Popp, F., et al. "TelomereHunter2: Improved In silico Telomere Analysis Software for Precision Oncology and Single-cell Studies." Bioinformatics Advances (2026). https://doi.org/10.1093/bioadv/vbag187